Endocrine Abstracts

Obesity is the modern medical problem. According to the WHO expert panel the prevalence of obese population worldwide is 300 million and overweight is 750 million.In the first trimester of 2007, we studied the obese patients in the Iv. Javakhishvili State Medical University’s Department of Endocrinology. The objective of our research was to study the course of subclinical hypothyroidism adjunct with severe obesity, its diagnostic criteria and treatm...

The aim of our study was to assess the advantage of combinative therapy with lisinopril and moxonidin for the treatment of arterial hypertension in group of obese patients in comparison to the single-drug therapy with lisinopril.Methods: 26 obese patients were divided in 2 groups. They underwent a 24-hour monitoring of the arterial pressure and were diagnosed as arterial hypertension II degree (ESH-ESC). In the I group for the purpose of stabiliza...

Introduction: Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism results in thermolabile, reduced functioning enzyme and predicts hyperhomocisteinemia and altered DNA methylation. On the other hand, several studies indicated a higher plasma homocysteine (Hcy) levels in patients with primary hypothyroidism than in healthy, euthyroid individuals, including some experimental studies that indicated decreased MTHFR activity in hypothyroid patients. We cond...

We have investigated the leptin production by total and regional fat mass in 32 overweight postmenopausal women as well as the relation between serum leptin levels, total body fat mass and body fat distribution variables. Body mass index (BMI) was calculated in kg/m2. Serum concentrations of leptin were evaluated by RIA. Body composition – trunk/total, arms+legs/total+legs/trunk, android/gynoid ratios were assessed by dual-energy X-ray absorptiometry (DEXA). Th...

Background: The cardiovascular complication is the main cause of morbidity and mortality in obese patients. Endothelial dysfunction and atherosclerosis have the goal role in development of these diseases. The aim of our study was to reveal the role of nitric oxide during obesity associated arterial hypertension.Subject and method: 200 obese patients (age 35–55) were investigated. Control group comprised 25 healthy subjects. We calculated BMI, determ...